Casting Channel Fundamental Runes
Six fundamental runes produce the most essential magic of protection and destruction: armor potency and resilient runes for armor, weapon potency and striking runes for weapons, and casting potency and heightening runes for casting channels. A potency rune is what makes a weapon a magic weapon or armor magic armor.
An item can have only one fundamental rune of each type, though etching a stronger rune can upgrade an existing rune to the more powerful version (as described in each rune’s entry). As you level up, you typically alternate between increasing an item’s potency rune and its striking, resilient, or heightening rune when you can afford to.